Vascular smooth muscle cell (SMC) relaxation by guanylyl cyclases (GCs) and cGMP is mediated by NO and its receptor soluble GC (sGC) or natriuretic peptides (NPs) ANP/BNP and CNP with the receptors GC-A and GC-B. respectively. It is commonly accepted that cultured SMCs differ from those in intact vessels. Nevertheless. https://www.chiggate.com/philadelphia-eagles-mitchell-ness-head-coach-hoodie-sale/