Abstract RNF2 is a RING domain-containing E3 ubiquitin ligase that mediate histone H2A mono-ubiquitination to repress gene transcription. but its expression patterns and molecular function in hepatocellular carcinoma (HCC) remain unclear. Herein. we extracted data from TGCA database and validated RNF2 expression in our own cohort. https://www.opheliasmuse.com/