Abstract Background Genetic variants within the fatty acid desaturase (FADS) gene cluster (human Chr11) are important regulators of long-chain (LC) polyunsaturated fatty acid (PUFA) biosynthesis in the liver and consequently have been associated with circulating LC-PUFA levels. More recently. epigenetic modifications such as DNA methylation. particularly within the FADS cluster. https://www.roneverhart.com/Verragio-Paradiso-Round-Diamond-Engagement-Ring-Setting-0-55-CTW-p5464/