Studies of homozygous PAR2 gene knockout mice have described a mix of phenotypic effects in vitro and in vivo. However. there have been few studies of PAR2 heterozygous (wild-type/knockout; PAR2-HET) mice. The phenotypes of many hemi and heterozygous transgenic mice have been described as intermediates between those of wild-type and knockout animals. https://parisnaturalfoodes.shop/product-category/shea-butter-hand-cream/